Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Biological goals and you can pharmacology of curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ’s the major element of the reddish color off turmeric, an enthusiastic Indian spice which is extracted from the fresh new rhizome of your own warm bush Curcuma longa, hence is one of the Zingiberaceae relatives. Within this part, i talk about the pharmacological circumstances out-of curcumin and you can discuss the fresh new unit basics for these things. We upcoming comment the newest confirmed and you may potential logical uses away from curcumin. Curcumin is well known typically once the a curative representative, but its system from action was detail by detail. The fresh pharmacological effects of curcumin appear to be the result of an effective synergism regarding networks out of weakened biochemical connections that have numerous biological purpose for the interconnected signaling paths. Such targets become enzymes instance cyclooxygenase, lipoxygenase and you may healthy protein kinases, and transcription products such as for instance NF-?B, STAT and you may Nrf2. Modulation of these particles has an effect on downstream affectors which make the new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial things off curcumin. Such outcomes have been looked at when you look at the systematic samples off curcumin to have soreness and inflammatory disease, malignant tumors, Alzheimer condition, aerobic disease, and you will diabetic issues. This new examples used variable dosage out-of curcuminwith various other wavelengths and you will course, with the standard end you to large amounts out of curcumin from the quantity of g are required to receive therapeutic consequences. Find out more
Curcumin: Synthesis, Emerging Part inside Serious pain Management and you may Health Effects
Book Part Types of plant-derived pharmaceuticals having get to be the focus out of continuing and you will exponential browse and you will development appeal possess, at this point, been some scarce. Just after years, the past two decades was in fact characterized by an excellent 100-bend increase in the number of medical stuff published annually that are away from benefit towards the access to curcumin into the biomedicine. Read more
Build, synthesis and biological facts from curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many potential pharmacological effects that can keeps therapeutic software in lots of disease states, due to the fact discussed in more detail in the last section. Yet not, the possibility systematic efficacy out-of curcumin is restricted by the physicochemical properties out-of bad h2o solubility and you will instability, which cause reasonable bioavailability. Prodrugs of curcumin bring an effective way to update of one’s biopharmaceutical and you trГ¤ffa Puerto Rico kvinnor will pharmacokinetic attributes, and will allow exploitation of pharmacological effects of curcumin. Within section, i basic comment the latest physicochemical and you will pharmacokinetics regarding curcumin. We next identify the appearance of curcumin prodrugs having improved drinking water solubility and you can enhanced chemical substances stability and this can be converted back to 100 % free curcumin up on bioactivation into the vivo. I focus on recent victory here, having a focus on the construction, synthesis and you may evaluation away from prodrugs centered on promoieties along with amino acids, efas, nucleic acids, dicarboxylic acids, and you can polymeric materials particularly hyaluronic acid and you may polyethylene glycol. Which part contains the cause for optimisation of physicochemical and you will biopharmaceutical features plus the physical points off curcumin prodrugs, for the mission using of those curcumin derivatives inside logical apps. Find out more
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